Antitumor-proinflammatory effect of IgE antibody directed against melanoma-associated antigen chondroitin sulfate proteoglycan 4 - citation forms (2023)

Antitumor-proinflammatory effect of IgE antibody directed against melanoma-associated chondroitin sulfate proteoglycan 4 antigen./ Chauhan, Jitesh; Grandits, Melanie; Palm, Lais CGF; Mele, Silvia; Nakamura, Mano; Lopez-Abente, James; Crescioli, Silvia; Laddach, Roman; Rosemary-Peg, Paul; Cheung, Anthony; Σταύρακα, Χαρά; Chenoweth , Alice M ; Sau, Heng Sheng? Chiaruttini, Giulia; Gilbert, Amy E; Dodev, Homir; Koers, Alexander; Pellizzari, Giulia; Ilieva, Christina M; Mann, Franjo; Ali, Niwa; Hobbs, Carl; Lombardi, Sarah; Lionarons, Daniel A; Gould, Hannah J; Beavil, Andrew J; Geh, Jenny LC; MacKenzie Ross, Alastair D; Healy, Ciaran; Calonje, Edward; Προς τα κάτω, Τζούλιαν. Nestlé, Frank O; Ανάσταση, Scientific; Josephs , Debra Η ; Geblase , Philip J. ( 1999 ).; Karagiannis, Panagiotis; Lacy, Katie E; Spicer, James; Karagiannis, Sophia N; Bax, Heather J.

U:COMMON NAC, Bd. 14, no. 1, April 25, 2023, S. 2192.

publications:EVALUATION: Article in a professional magazine/newspaper›EVALUATION: Article in the magazine›Research›Evaluation

Chauhan , J , Grandits , M , Palmhares , LCGF , Mele , S , Nakamura , M , Lopez-Abente , J , Crescioli , S , Laddach , R , Rosemary-Peg , P , Cheung , A , Stavraka , AM , Sow , HS , Chiaruttini , G , Gilbert , AE , Dodev , T , Koers , A , Pellizzari , G , Ilieva , KM , Man , F , Ali , N , Hobbs , C , Lombardi , S , Lionarons , HJ , Beavil , AJ , Geh , JLC , MacKenzie Ross , AD , Healy , C , Calonje , E , Downward , J , Nestle , FO , Rise , S , Josephs , DH , Blower , PJ, Karagiannis, P, Lacy, KE, Spicer, J, Karagiannis, SN & Bax, HJ 2023, 'Antitumor proinflammatory effects of IgE antibodies directed against melanoma-associated chondroitin sulfate proteoglycan 4 antigen',COMMON NAC, Jg. 14, br. 1, S. 2192.https://doi.org/10.1038/s41467-023-37811-3

Chauhan , J , Grandits , M , Palhares , LCGF , Mele , S , Nakamura , M , Lopez-Abente , J , Crescioli , S , Laddach , R , Rosemary-Peg , P , Cheung A. , Stavraka , C. , Chenoweth , A.M. , Sow , H.S. , Chiaruttini , G. , Gilbert , A.E. , Dodev , T. , Koers , A. , Pellizzari , G. , Ilieva , K.M. , H.J.3 . ).Antitumor proinflammatory effects of IgE antibodies directed against melanoma-associated chondroitin sulfate proteoglycan 4 antigen.COMMON NAC,14(1), 2192.https://doi.org/10.1038/s41467-023-37811-3

Chauhan J, Grandits M, Palhares LCGF, Mele S, Nakamura M, López-Abente J et al.Antitumor proinflammatory effects of IgE antibodies directed against melanoma-associated chondroitin sulfate proteoglycan 4 antigen.COMMON NAC. April 25, 2023; 14(1): 2192.https://doi.org/10.1038/s41467-023-37811-3

@article{3685add716ce4cb08be8a6faabae412d,

title = "Antitumor-proinflammatory effect of IgE antibody directed against melanoma-associated antigen chondroitin sulfate proteoglycan 4",

summary = “Outcomes remain poor in half of melanoma patients despite standard checkpoint inhibitor therapies. The prevalence of melanoma-associated chondroitin sulfate proteoglycan 4 (CSPG4) antigen expression is ~70%, therefore effective CSPG4-targeted immunotherapies can be made with respect to IgE action. Because of its potent immunostimulatory functions in tissues, we are developing a monoclonal IgE human constant region antibody that recognizes CSPG4 to target melanoma monocytes expressing the IgE Fc receptor for proinflammatory phenotypes. IgE exhibits antitumor activity in human melanoma xenograft models transplanted with human effector cells and is associated with increased macrophage infiltration, enriched monocyte and macrophage gene signatures, and proinflammatory signaling pathways. IgE in the tumor microenvironment prolongs the survival of patient-derived mice bearing xenografts reconstituted with autologous immune cells. Ex vivo activation of basophils in the blood of patients in the presence of CSPG4-IgE was not measured. "Our results support the promise of IgE-based melanoma immunotherapy,"

συγγραφέας = "Jitesh Chauhan and Melanie Grandits and Palhares, Silvia Mele and Mano Nakamura and James L{\'o}pez-Abente and Silvia Crescioli and Roman Laddach and Pablo Romero-Clavijo and Anthony Cheung and Chara Stavraka and Chenoweth, Alicia M Sow , Heng Sheng Giulia Chiaruttini Gilbert, Amy E Tihomir Dodev Alexander Koers Giulia Pellizzari Ilieva, Kristina M Francis Man Niwa Ali An Carl Hobbs An Sarah Lombardi i Lionarons, Dani i Gould, Hannah J i Beavil, Andrew J i Geh, Jenny L C i MacKenzie Ross, Alastair D, Ciaran Healy, Eduardo Calonje, Julian Downward, Nestle, Frank O, Sophia Tsoka, Josephs, Debra H, Blower, Philip J, Panagiotis Karagiannis, Lacy, Katie E, i James Spicer, i Karagiannis, i Bax, {Heather J}",

note = "{\textcopyright} 2023. Autori",

year = "2023",

month = April,

Label = "25",

dva = "10.1038/s41467-023-37811-3",

language="english",

volume = "14",

pages="2192",

log="NAT COMMON",

issn = „2041-1723“,

editor = "NADAVAČKA GRUPA PRIRODA",

number = "1",

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VI - MARK

T1 - Antitumor-proinflammatory effect of IgE antibody directed against melanoma-associated antigen chondroitin sulfate proteoglycan 4

AU – Chauhan, Jitesh

AU – Grandits, Melanie

AU - Palhares, Lais C G F

AU – My God, Silvia

ICH – Nakamura, Mano

AU - López-Abente, Jacobo

AU - Crescioli, Silvia

AU - Laddach, rimski

AU - Romero-Clavijo, Pablo

AU – Cheung, Anthony

AU – Stavraka, Chara

AU – Chenoweth, Alicia M

AU – Shaw, Heng Sheng

AU – Chiaruttini, Giulia

AU - Gilbert, Amy E

AU – Dodev, Tihomir

AU - Rate, Alexander

AU – Pellizzari, Giulia

AU - Ilieva, Kristina M

AU – Mann, Francis

YES - Good, breath

AU – Hobbs, Carl

AU – Lombardi, Sara

AU - Lionarons, Daniel A

AU - Gould, Hannah J

AU - Beavil, Andrew J

AU - God, Jenny LC

AU – MacKenzie Ross, Alastair D

AU – Healy, Ciaran

AU - Calonje, Eduardo

AU — Nieder, Julian

AU - Nestlé, Frank O

AU - Probudi Sophiu

AU - Josephs, Debra H

AU – Blower, Philip J

AU – Karagiannis, Panagiotis

AU – Lacy, Katie E

AU – Spicer, James

S.A. - Karagiannis, Sofia N

AU - Bax, Heather J

N1 - © 2023. Authors.

GJ – 25.04.2023

1st year – 25.04.2023

N2 - Outcomes remain poor in half of melanoma patients despite standard checkpoint inhibitor treatments. The prevalence of melanoma-associated chondroitin sulfate proteoglycan 4 (CSPG4) antigen expression is about 70%, so effective immunotherapies against CSPG4 could benefit many patients. Because IgE has potent immunostimulatory functions in tissues, we are developing an IgE monoclonal antibody with human constant regions that recognizes CSPG4 to target melanoma. CSPG4-IgE binds to human melanomas, including metastases, mediates tumoricidal antibody-dependent cytotoxicity, and stimulates human IgE Fc receptor-expressing monocytes toward proinflammatory phenotypes. IgE exhibits antitumor activity in human melanoma xenograft models transplanted with human effector cells and is associated with increased macrophage infiltration, enriched monocyte and macrophage gene signatures, and proinflammatory signaling pathways in the tumor microenvironment. IgE prolongs the survival of patient-derived mouse xenografts reconstituted with autologous immune cells. Ex vivo activation of basophils in the blood of patients in the presence of CSPG4-IgE was not measured. Our results support the promising IgE-based immunotherapy of melanoma.

AB - Outcomes remain poor in half of melanoma patients despite standard checkpoint inhibitor therapies. The prevalence of melanoma-associated chondroitin sulfate proteoglycan 4 (CSPG4) antigen expression is about 70%, so effective immunotherapies against CSPG4 could benefit many patients. Because IgE has potent immunostimulatory functions in tissues, we are developing an IgE monoclonal antibody with human constant regions that recognizes CSPG4 to target melanoma. CSPG4-IgE binds to human melanomas, including metastases, mediates tumoricidal antibody-dependent cytotoxicity, and stimulates human IgE Fc receptor-expressing monocytes toward proinflammatory phenotypes. IgE exhibits antitumor activity in human melanoma xenograft models transplanted with human effector cells and is associated with increased macrophage infiltration, enriched monocyte and macrophage gene signatures, and proinflammatory signaling pathways in the tumor microenvironment. IgE prolongs the survival of patient-derived mouse xenografts reconstituted with autologous immune cells. Ex vivo activation of basophils in the blood of patients in the presence of CSPG4-IgE was not measured. Our results support the promising IgE-based immunotherapy of melanoma.

U2 – 10.1038/s41467-023-37811-3

DO – 10.1038/s41467-023-37811-3

M3 – GRADE: Article in a magazine

C2 - 37185332

VL - 14

SP - 2192

YES - NIGHT COMMUNICATION

JF - COMMON NAT

SN - 2041-1723

IS - 1

IS -